Plant-based immunocontraceptive control of wildlife : "potentials, limitations, and possums"
Identifieur interne : 00A500 ( Main/Exploration ); précédent : 00A499; suivant : 00A501Plant-based immunocontraceptive control of wildlife : "potentials, limitations, and possums"
Auteurs : Ian Polkinghome [Australie] ; Denes Hamerli [Australie] ; Phil Cowan [Nouvelle-Zélande] ; Janine Duckworth [Nouvelle-Zélande]Source :
- Vaccine [ 0264-410X ] ; 2005.
Descripteurs français
English descriptors
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Abstract
Possums (Trichosurus vulpecula), originally introduced from Australia, are spread over 90% of New Zealand and cause major economic and environmental damage. Immunocontraception has been suggested as a humane means to control them. Marsupial-specific reproductive antigens expressed at high levels in edible transgenic plant tissue might provide a safe, effective, and cheap oral delivery bait for immunocontraceptive control. As proof of concept, female possums vaccinated with immunocontraceptive antigens showed reduced fertility, and possums fed with potato-expressed heat labile toxin-B (LT-B) had mucosal and systemic immune responses to the antigen. This demonstrated that immunocontraception was effective in possums and that oral delivery in edible plant material might be possible. Nuclear transformation with reporter genes showed that transgenic carrot roots accumulate high levels of foreign protein in edible tissues, indicating their potential as a delivery vector. However, prior to attempts at large scale production, more effective immunocontraceptive antigen-adjuvant formulations are probably required before plant-based immunocontraception can become a major tool for immunocontraceptive control of overabundant vertebrate pests.
Affiliations:
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aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St. Lucia Q4072</wicri:noRegion></affiliation></author><author><name sortKey="Cowan, Phil" sort="Cowan, Phil" uniqKey="Cowan P" first="Phil" last="Cowan">Phil Cowan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Landcare Research</s1><s2>Lincoln, Canterbury</s2><s3>NZL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Landcare Research</wicri:noRegion></affiliation></author><author><name sortKey="Duckworth, Janine" sort="Duckworth, Janine" uniqKey="Duckworth J" first="Janine" last="Duckworth">Janine Duckworth</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Landcare Research</s1><s2>Lincoln, Canterbury</s2><s3>NZL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Landcare Research</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno 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Polkinghome</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Bioscience Precinct, L6 Nth Tower, University of Queensland</s1><s2>St. Lucia Q4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St. Lucia Q4072</wicri:noRegion></affiliation></author><author><name sortKey="Hamerli, Denes" sort="Hamerli, Denes" uniqKey="Hamerli D" first="Denes" last="Hamerli">Denes Hamerli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Bioscience Precinct, L6 Nth Tower, University of Queensland</s1><s2>St. Lucia Q4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St. Lucia Q4072</wicri:noRegion></affiliation></author><author><name sortKey="Cowan, Phil" sort="Cowan, Phil" uniqKey="Cowan P" first="Phil" last="Cowan">Phil Cowan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Landcare Research</s1><s2>Lincoln, Canterbury</s2><s3>NZL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Landcare Research</wicri:noRegion></affiliation></author><author><name sortKey="Duckworth, Janine" sort="Duckworth, Janine" uniqKey="Duckworth J" first="Janine" last="Duckworth">Janine Duckworth</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Landcare Research</s1><s2>Lincoln, Canterbury</s2><s3>NZL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Landcare Research</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Vaccin</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Possums (Trichosurus vulpecula), originally introduced from Australia, are spread over 90% of New Zealand and cause major economic and environmental damage. Immunocontraception has been suggested as a humane means to control them. Marsupial-specific reproductive antigens expressed at high levels in edible transgenic plant tissue might provide a safe, effective, and cheap oral delivery bait for immunocontraceptive control. As proof of concept, female possums vaccinated with immunocontraceptive antigens showed reduced fertility, and possums fed with potato-expressed heat labile toxin-B (LT-B) had mucosal and systemic immune responses to the antigen. This demonstrated that immunocontraception was effective in possums and that oral delivery in edible plant material might be possible. Nuclear transformation with reporter genes showed that transgenic carrot roots accumulate high levels of foreign protein in edible tissues, indicating their potential as a delivery vector. However, prior to attempts at large scale production, more effective immunocontraceptive antigen-adjuvant formulations are probably required before plant-based immunocontraception can become a major tool for immunocontraceptive control of overabundant vertebrate pests.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Nouvelle-Zélande</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Polkinghome, Ian" sort="Polkinghome, Ian" uniqKey="Polkinghome I" first="Ian" last="Polkinghome">Ian Polkinghome</name></noRegion><name sortKey="Hamerli, Denes" sort="Hamerli, Denes" uniqKey="Hamerli D" first="Denes" last="Hamerli">Denes Hamerli</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Cowan, Phil" sort="Cowan, Phil" uniqKey="Cowan P" first="Phil" last="Cowan">Phil Cowan</name></noRegion><name sortKey="Duckworth, Janine" sort="Duckworth, Janine" uniqKey="Duckworth J" first="Janine" last="Duckworth">Janine Duckworth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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